Triethylamine → 4-Cyclobutanecarbonyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

Cyclobutanecarbonyl chloride (3.7 ml) and triethylamine (14 ml) were added to a solution of [1,4]diazepane-1-carboxylic acid tert-butyl ester (4.9 ml) in dichloromethane (175 ml). After stirring for 1 h at room temperature, the reaction mixture was washed with water, an aqueous HCl solution (1 N), water and brine. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.

Provenance & Evidence