Butyl iodide → HCID 44181499, compound

Participants

Reaction Steps

Sodium hydride (160 mg, 60% dispersion in oil) was added to a solution of the product of example 13 (767 mg) in DMF (24 ml). After stirring for 5 min at room temperature, 1-iodobutane (1.46 ml) was added and stirring was continued for 18 h at 60° C. The reaction mixture was poured in a sat. aqueous NH4Cl solution and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel in dichloromethane/methanol [100/0→90/0 (v/v)] as eluent.

Provenance & Evidence