HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 58147649, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Tert-butyl 1,4-diazepane-1-carboxylate | HCID 2756058 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58147649 | HCID 58147649 | — |
Reaction Steps
HATU (1.71 g), [1,4]diazepane-1-carboxylic acid tert-butyl ester (0.813 ml) and DIPEA (3.58 ml) were added to a solution of the product of example 104b (470 mg) in dichloromethane (20 ml). After stirring for 2 h at room temperature, the reaction mixture was poured in an aqueous citric acid solution (10%) and extracted with ethyl acetate. The organic layer was washed with a sat. aqueous NaHCO3 solution, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by chromatography on silica in toluene/acetone [100/0→3/1 (v/v)] as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394789B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0578fcd9418140baaf89c27f395e1bfc |
| Source note | uspto-grants-2013_03 |