HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 2-[4-(hydroxymethyl)phenyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 4-(Hydroxymethyl)phenylacetic acid | HCID 3283498 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-[4-(hydroxymethyl)phenyl]acetate | HCID 12575321 | — |
Reaction Steps
To 2-(4-(hydroxymethyl)phenyl)acetic acid in MeOH at 0° C. was added TMS-CHN2. The solution was stirred for 3 h then quenched with a few drops of AcOH. The solvents were evaporated. Column chromatography (SiO2, 3-15% EtOAc/Hex) gave pure methyl 2-(4-(hydroxymethyl)phenyl)acetate (E132).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394826B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-cc34defc08ff4f6e8d58b852fd32190c |
| Source note | uspto-grants-2013_03 |