Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 59563764 | HCID 59563764 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59563703 | HCID 59563703 | — |
Reaction Steps
To tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate (E138) in THF at 0° C. was added TBAF, and the solution was stirred for 45 min at 0° C. The compound was poured into EtOAc and washed with NH4Cl(sat), dried (MgSO4), filtered, and evaporated. Column chromatography (SiO2, 6% MeOH/CH2Cl2) gave pure tert-butyl 2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate (E139).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08394826B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-151716ef5d884993a8041b35b49ad3f5 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
