Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | Triisopropylsilyl trifluoromethanesulfonate | HCID 2724529 | — |
| Reactant | Benzyl 2-(4-hydroxyphenyl)acetate | HCID 11107524 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59563750 | HCID 59563750 | — |
Reaction Steps
To benzyl 2-(4-hydroxyphenyl)acetate (E301) in CH2Cl2 at 0° C. was added 2,6-lutidine and TIPS-OTf and the solution stirred for 2.5 h at 0° C. The mixture was poured into NH4Cl(sat) and extracted with CH2Cl2. The combined organics were dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 0-15% EtOAc/Hex) gave pure benzyl 2-(4-(triisopropylsiloxy)phenyl)acetate (E302).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08394826B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-84a72d5834024a76bedb9b50546b53d2 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
