HCID 68490281, compound → HCID 68494343, compound

Participants

Reaction Steps

7-Ethoxy-6-benzyloxy-2-(3,4,5-trimethoxybenzyl)-tetrahydroisoquinoline acetate (307 mg, 0.66 mmol) was dissolved in ethanol and ethyl acetate (5 mL each), degassed, treated with 10% Pd/C (50 mg) then placed under an atmosphere of hydrogen. After 0.5 h no starting material was evident by TLC and the reaction was filtered through celite and evaporated. The resultant oil was precipitated from ethyl acetate/hexane to give a yellow powder (240 mg, 97%). 1H NMR δ 1.39 (3H, t, J 7.0), 2.68 (2H, t, J 5.7), 2.75 (2H, t, J 5.7), 3.52 (2H, s), 3.58 (2H, s), 3.83 (3H, s), 3.84 (6H, s), 4.01 (2H, q, J 7.0), 5.50 (1H, br), 6.46 (1H, s), 6.61 (2H, s) and 6.67 (1H, s).

Provenance & Evidence