Tetrahydrofuran → HCID 68490057, compound

Participants

Reaction Steps

A solution of 2-benzyl-7-(benzyloxy)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one (1 mmol) in THF (20 mL) and methanol (20 mL) was treated with 10% Pd/C (40 mg) and stirred under an atmosphere of hydrogen. The reaction was monitored by TLC. Upon completion, the resultant suspension was filtered through celite, washed with ethyl acetate and then evaporated under reduced pressure. The resulting solid was stirred in diethyl ether, filtered and dried under vacuum or purified by flash chromatography (hexane/ethyl acetate) then stirred in diethyl ether, filtered and dried under vacuum.

Provenance & Evidence