Methanol → HCID 91576878, compound

Participants

Reaction Steps

F11 (5.4 g, 13.5 mmol) was stirred in THF (80 mL) and methanol (10 mL) and cooled to 0° C. before acetyl chloride (5.8 mL, 80 mmol) was added drop wise. The solution was stirred at rt o/n, After addition of DCM (100 mL), the organic layer was successively washed with saturated aqueous NaHCO3, water and brine, dried (MgSO4), filtered and concentrated to afford 4.2 g of a crude dark yellow solid. Column chromatography (petroleum ether/ethyl acetate 9/1 to 0/1 then ethyl acetate/methanol 1/0 to 10/1) afforded 1.8 g (45%) of 6-Benzyloxy-4,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline F12 and 6-benzyloxy-7-methoxyisoquinoline F13 (400 mg, 11%);

Provenance & Evidence