Hydrochloric Acid → HCID 58171832, compound

Participants

Reaction Steps

To a solution of 1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-4-carboxylic acid ethyl ester (1.41 g, 5.89 mmol) in ethanol (5 ml) was added a 1 M solution of sodium hydroxide (5.9 ml, 5.9 mmol). The solution was stirred for 18 h at RT, and then was acified by addition of a 1 M solution of hydrochloric acid (5.9 ml). The reaction mixture was concentrated in vacuo. After the addition of Na2SO4 the residue was suspended in THF (20 ml), filtered off and washed with THF and dried under vacuo. The title compound (0.72 g, 38%) was obtained as an off-white solid. MS m/e: 210.1 [M−H].

Provenance & Evidence