Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944335Generated: October 31, 2026

Chlorodifluoromethane → [4-Difluoromethoxy-8-fluoro-2-isopropyl-3-(4-pyrazol-1-ylbenzyl)quinolin-5-yloxy]acetic acid methyl ester

https://huagongshe.com/reaction/1944335

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorodifluoromethaneHCID 6372—
Reactant[8-Fluoro-2-isopropyl-4-oxo-3-(4-pyrazol-1-ylbenzyl)-1,4-dihydroquinolin-5-yloxy]acetic acid methyl esterHCID 67459089—
Product[4-Difluoromethoxy-8-fluoro-2-isopropyl-3-(4-pyrazol-1-ylbenzyl)quinolin-5-yloxy]acetic acid methyl esterHCID 67458279—

Reaction Steps

The title compound was prepared by the method of Preparation 10c using [8-fluoro-2-isopropyl-4-oxo-3-(4-pyrazol-1-ylbenzyl)-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester and chlorodifluoromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394830B2
Source datasetuspto-grants-2013_03
ORD IDord-9fbd1e3154054ee2bdca0e9c1812fb97
Source noteuspto-grants-2013_03