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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944342Generated: October 29, 2026

3-Cyclopropyl-1H-pyrazole → {3-[4-(5-Cyclopropylpyrazol-1-yl)benzyl]-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy}acetic acid methyl ester

https://huagongshe.com/reaction/1944342

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Cyclopropyl-1H-pyrazoleHCID 7017816—
Reactant(4-{[4-Difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy) quinolin-3-yl]methyl}phenyl)boronic acidHCID 67458287—
Product{3-[4-(5-Cyclopropylpyrazol-1-yl)benzyl]-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy}acetic acid methyl esterHCID 67457311—

Reaction Steps

The title compound was prepared by the method of Preparation 23b using (4-{[4-difluoromethoxy-2-ethyl-8-fluoro-5-(2-methoxy-2-oxoethoxy)quinolin-3-yl]methyl}phenyl)boronic acid and 5-cyclopropyl-1H-pyrazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394830B2
Source datasetuspto-grants-2013_03
ORD IDord-63ce64a5c5bf40bcac650bb91244a44f
Source noteuspto-grants-2013_03