1H-Pyrazole-4-boronic acid → HCID 25096833, compound

HRID 1944351Notes

Reaction equation

HRID 1944351 reaction equation
C([O:5][C:6](=[O:33])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:32])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28](Br)=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)(C)(C)C.[NH:34]1[CH:38]=[C:37](B(O)O)[CH:36]=[N:35]1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:33])=[C:10]2[C:15]=1[N:14]=[C:13]([O:20][CH:21]([F:22])[F:23])[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:37]3[CH:38]=[N:34][NH:35][CH:36]=3)=[CH:27][CH:26]=1)=[C:11]2[CH3:32]

Participants

3

Reactant 2

HCID 177502781H-Pyrazole-4-boronic acidHCID 67458314[3-(4-Bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl ester

Product 1

HCID 25096833HCID 25096833, compound

Procedure

The title compound was prepared by the method of Preparation 22b using [3-(4-bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl ester and pyrazole-4-boronic acid.

Sources & evidence

ORD record
ord-3bc6166e6e6c475cb944736e600d7897
Source dataset
uspto-grants-2013_03
Patent number
US08394830B2

Reaction notes

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