HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyclopropyl-1H-pyrazole → {8-Chloro-3-[4-(4-cyclopropylpyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyclopropyl-1H-pyrazole | HCID 13163973 | — |
| Reactant | {8-Chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67458465 | — |
| Product | {8-Chloro-3-[4-(4-cyclopropylpyrazol-1-yl)benzyl]-2-difluoromethoxy-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67457844 | — |
Reaction Steps
The title compounds was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 4-cyclopropyl-1H-pyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394830B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-9a043218bc9e47e4b836b8c1d7a1f207 |
| Source note | uspto-grants-2013_03 |