Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → {3-[2-(4-Chlorobenzenesulfonyl)pyridin-3-ylmethyl]-5-fluoro-2-methylindol-1-yl}acetic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[CH:7]=[C:6]1[CH3:15].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([C:27]2[C:32]([CH:33]=O)=[CH:31][CH:30]=[CH:29][N:28]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3](=[O:16])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C:7]([CH2:33][C:32]2[C:27]([S:24]([C:21]3[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=3)(=[O:26])=[O:25])=[N:28][CH:29]=[CH:30][CH:31]=2)=[C:6]1[CH3:15]Participants
3
Procedure
The title compound was prepared by the method of Preparation 1c using (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester and 2-(4-chlorobenzenesulfonyl)pyridine-3-carbaldehyde.
Sources & evidence
- ORD record
- ord-6af10cc1989f4178b50fa4361e7687ff
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
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