反应详情

温度

100 °C

A mixture of 3-fluoropyridine-2-carbaldehyde (0.70 g), 4-fluorobenzenesulfinic acid sodium salt (1.1 g) and dimethyl sulfoxide (7.0 mL) was stirred at 100° C. for 18 hours. The mixture was cooled to room temperature, diluted with water (20 mL), and the resulting precipitate was removed by filtration. The filtrate was extracted with ethyl acetate, and the combined organic extract was washed with saturated aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a pale yellow oil (0.67 g).

1. temperatureThe mixture was cooled to room temperature
2. customthe resulting precipitate was removed by filtration
3. extractionThe filtrate was extracted with ethyl acetate
4. extractionthe combined organic extract
5. washwas washed with saturated aqueous sodium chloride solution
6. dry with materialdried over magnesium sulfate
7. customThe solvent was removed under reduced pressure