4-Formyl-3-(phenylsulfonyl)benzonitrile → [3-(2-Benzenesulfonyl-4-cyanobenzyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester

HRID 1944414Notes

Reaction equation

HRID 1944414 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=2[CH:18]=O)[C:13]#[N:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:20][O:21][C:22](=[O:35])[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([F:33])=[CH:30][CH:31]=2)[CH:26]=[C:25]1[CH3:34]>>[CH3:20][O:21][C:22](=[O:35])[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([F:33])=[CH:30][CH:31]=2)[C:26]([CH2:18][C:17]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][C:10]=2[S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:8])=[O:9])=[C:25]1[CH3:34]

Participants

3

Reactant 2

HCID 581337454-Formyl-3-(phenylsulfonyl)benzonitrileHCID 58247161Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate

Product 1

HCID 67044517[3-(2-Benzenesulfonyl-4-cyanobenzyl)-5-fluoro-2-methylindol-1-yl]acetic acid methyl ester

Procedure

The title compound was prepared by the method of Preparation 1c using 3-benzenesulfonyl-4-formylbenzonitrile and (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester.

Sources & evidence

ORD record
ord-92ebca48bddc42a78c35c1915ef58724
Source dataset
uspto-grants-2013_03
Patent number
US08394836B2

Reaction notes

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