反应详情

温度

80 °C

A mixture of 3-chlorothiophene-2-carbaldehyde (0.16 g), pyridine-3-sulfinic acid sodium salt (0.30 g) and dimethyl sulfoxide (2.0 mL) was heated at 80° C. for 3 hours and then at 90° C. for 3 hours. The mixture was diluted with water, extracted with ethyl acetate and the combined organic extract was dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a grey solid (0.079 g).

1. extractionextracted with ethyl acetate
2. extractionthe combined organic extract
3. dry with materialwas dried over magnesium sulfate
4. customThe solvent was removed under reduced pressure