Methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate → {3-[2-(3-Chlorobenzenesulfonyl)pyridin-3-ylmethyl]-5-fluoro-2-methylindol-1-yl}acetic acid methyl ester
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[C:16]([CH:17]=O)=[CH:15][CH:14]=[CH:13][N:12]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:19][O:20][C:21](=[O:34])[CH2:22][N:23]1[C:31]2[C:26](=[CH:27][C:28]([F:32])=[CH:29][CH:30]=2)[CH:25]=[C:24]1[CH3:33]>>[CH3:19][O:20][C:21](=[O:34])[CH2:22][N:23]1[C:31]2[C:26](=[CH:27][C:28]([F:32])=[CH:29][CH:30]=2)[C:25]([CH2:17][C:16]2[C:11]([S:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:9])=[O:10])=[N:12][CH:13]=[CH:14][CH:15]=2)=[C:24]1[CH3:33]Participants
3
Procedure
The title compound was prepared by the method of Preparation 1c using 2-(3-chlorobenzenesulfonyl)pyridine-3-carbaldehyde and (5-fluoro-2-methylindol-1-yl)acetic acid methyl ester.
Sources & evidence
- ORD record
- ord-2834ef250f8141aa8bcb4fb93cdefded
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
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