Aluminium lithium hydride → HCID 67043922, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(methylphenylsulfamoyl)nicotinic acid methyl ester (1.5 g) and tetrahydrofuran (50 mL) at −78° C. was treated with a 1.0 M solution of lithium aluminium hydride in tetrahydrofuran (10 mL), and the resulting mixture was stirred at −78° C. for 1 hour and then at room temperature for 2 hours. The mixture was diluted with water, extracted with ethyl acetate and the combined organic extract was dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (1:0 to 19:1 by volume) to afford the title compound (0.25 g).

Provenance & Evidence