Methyl 2-(5-chloro-2-methyl-1H-indol-1-yl)acetate → {5-Chloro-2-methyl-3-[3-(pyridine-2-sulfonyl)thiophen-2-ylmethyl]indol-1-yl}acetic acid methyl ester
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([C:10]1[CH:14]=[CH:13][S:12][C:11]=1[CH:15]=O)(=[O:9])=[O:8].[CH3:17][O:18][C:19](=[O:32])[CH2:20][N:21]1[C:29]2[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=2)[CH:23]=[C:22]1[CH3:31]>>[CH3:17][O:18][C:19](=[O:32])[CH2:20][N:21]1[C:29]2[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=2)[C:23]([CH2:15][C:11]2[S:12][CH:13]=[CH:14][C:10]=2[S:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)(=[O:8])=[O:9])=[C:22]1[CH3:31]Participants
3
Procedure
The title compound was prepared by the method of Preparation 29a using 3-(pyridine-2-sulfonyl)thiophene-2-carbaldehyde and (5-chloro-2-methylindol-1-yl)acetic acid methyl ester.
Sources & evidence
- ORD record
- ord-09603ec7f8a94c689e8bc526fbb46555
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394836B2
Reaction notes
Loading…