反应详情

温度

100 °C

A mixture of 4-chlorothiazole-5-carbaldehyde (0.15 g), benzenesulfinic acid sodium salt (0.25 g) and dimethyl sulfoxide (7.0 mL) was stirred at 100° C. for 30 minutes. The mixture was cooled to room temperature, poured onto ice/water (50 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a tan oil (0.23 g).

1. temperatureThe mixture was cooled to room temperature
2. additionpoured onto ice/water (50 mL)
3. extractionextracted with ethyl acetate
4. extractionThe combined organic extract
5. washwas washed with saturated aqueous sodium chloride solution
6. dry with materialdried over magnesium sulfate
7. customThe solvent was removed under reduced pressure