2-Thiazolemethanol, 4-(2-chlorophenyl)-, 2-methanesulfonate → 4-(2-Chlorophenyl)-1,3-thiazole-2-carbaldehyde

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Reaction Steps

(4-(2-Chlorophenyl)thiazol-2-yl)methyl methane-sulfonate 4 from Step C above (0.10 g, 0.51 mmol) is dissolved in dichloromethane (4.0 mL), followed by addition of manganese dioxide (0.18 g, 2 mmol). The suspension is vigorously stirred at room temperature overnight. Filtration and concentration yielded 4-(2-chlorophenyl)thiazole-2-carbaldehyde 5 as a light-brown oil: MS calcd. for C10H7ClNOS (M+H+) 224.0. found 224.0.

Provenance & Evidence