Ethanol → HCID 59187437, compound

Participants

Reaction Steps

{4-[4-(2-Bromo-phenyl)-thiazol-2-ylmethoxy]-2-methyl-phenoxy}-acetic acid methyl ester (30 mg, 0.067 mmol), cyclopropylboronic acid (6.9 mg, 0.080 mmol) and sodium carbonate (21 mg, 0.20 mmol) are dissolved in water (120 μL), ethanol (90 μL) and 1,2-dimethoxyethane (360 μL). Pd(PPh3)4 (10 mol %) is added, and the mixture is subjected to microwave (180° C.) for 5 min in a sealed tube to give crude methyl 2-(4-((4-(2-cyclopropylphenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetate, which is used without further purification in Step B.

Provenance & Evidence