Bromocyclopentane → HCID 59187449, compound

Participants

Reaction Steps

2-(4-((4-(3-hydroxyphenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic acid (20 mol, 0.052 mmol) is dissolved in acetone (4 mL). K2CO3 (21 mg, 0.156 mmol) is added, followed by cyclopentyl bromide (38 μL, 0.259 mmol) and the resulting mixture is heated to reflux for 18 h. The solvent is evaporated in vacuo to give crude methyl 2-(4-((4-(3-(cyclopentyloxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetate, which is used in Step B without further purification.

Provenance & Evidence