Hydrochloric Acid → HCID 25018095, compound

Participants

Reaction Steps

The crude 6-{[4-(2-chloro-phenyl)-thiazol-2-ylmethyl]-amino}-naphthalene-2-carboxylic acid methyl ester from Step A is dissolved in THF (1 mL). A solution of 1 M LiOH in H2O (1 mL) is added and the mixture is stirred for 12 h at rt. The mixture is acidified with 1 M HCl (1 mL) and extracted into EtOAc (20 mL). The organic layer is dried (MgSO4), filtered, concentrated and purified on reverse phase HPLC (H2O/MeCN gradient) to afford the title compound G1 as a white solid: MS calcd. for C21H16ClN2O2S (M+H+) 395.9. found 396.0.

Provenance & Evidence