HCID 66815552, compound → HCID 59859896, compound

Participants

Reaction Steps

A solution of 3-(4-azepan-1-yl-phenyl)-acrylic acid ethyl ester (1.0 g, 3.65 mmol) in ethanol (20 Ml) was hydrogenated at 55 psi over 10% palladium (0.1 g) for 18 hours. The catalyst was removed by filtration, and the solvent was evaporated in vacuo. The crude product was purified by flash silica gel chromatography, using 5% ethyl acetate in hexane as the eluant, to give the product, 1.0 g (99%), a color less oil. MS: m/z 276 (MH+). 1H NMR (CDCl3): 1.24 (t, 3 H), 1.48-1.61 (m, 4 H), 1.76 (m, 4 H), 2.56 (t, 2 H), 2.84 (t, 2 H), 3.42 (t, 4 H), 4.13 (q, 2 H), 6.61 (d, 2 H) and 7.03 (d, 2 H).

Provenance & Evidence