Diethyl (ethoxymethylene)malonate → Diethyl 2-[(4-fluoroanilino)methylene]malonate

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluoro-phenylamine (5.1 mL, 54.4 mmol) and diethyl ethoxymethylenemalonate (10 mL, 49.5 mmol) was heated at 100° C. for 4 hours, an oil which solidified on cooling. The solid was triturated in heptane, collected by filtration and washed with heptane, to give the product as a colorless solid, 10.5 g (75%). MS: m/z 282.1 (MH+).

Provenance & Evidence