1,2-Dichloroethane → HCID 86616984, compound

Participants

Reaction Steps

To a solution of N-benzyl-1-(2-trans-methylcyclopropyl)methanamine hydrochloride (intermediate 3.2.1, 10 g, 47.2 mmol) in CHCl3 (150 mL) was added diisopropylethyl amine (9.87 mL, 56.7 mmol), methoxyacetic acid (4.35 mL, 56.7 mmol), HOAt (1.29 g, 9.5 mmol) and EDC (10.87 g, 56.7 mmol), and the reaction mixture was stirred at rt for 18 h. The reaction mixture was concentrated in vacuo, diluted with EtOAc, washed with 10% KHSO4, aq NaHCO3 and brine, dried over sodium sulfate and concentrated in vacuo to give trans N-benzyl-2-methoxy-N-[(2-methylcyclopropyl)methyl]acetamide which was used as is in the next step.

Provenance & Evidence