Methyl 2,6-dichloroisonicotinate → 2-Chloro-6-[methyl(methylsulfonyl)amino]isonicotinic acid

HRID 1944570Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10](Cl)[N:11]=1)[C:5]([O:7]C)=[O:6].[CH3:13][NH:14][S:15]([CH3:18])(=[O:17])=[O:16]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([N:14]([CH3:13])[S:15]([CH3:18])(=[O:17])=[O:16])[N:11]=1)[C:5]([OH:7])=[O:6]

Participants

Reactant 2

HCID 93237Methyl 2,6-dichloroisonicotinate

HCID 97632N-Methylmethanesulfonamide

Product 1

HCID 167483252-Chloro-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Procedure

Prepared from Methyl 2,6-dichloroisonicotinate and methyl(methylsulfonyl)amine as described in the preparation of intermediate 4.2c.1, steps A and B.

Sources & evidence

ORD record: ord-640cceed3d104e31bf4d331a46db364c
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394837B2

Reaction notes

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