Methyl 2,6-dichloroisonicotinate → HCID 59028312, compound

HRID 1944575Notes

Reaction equation

ClC1[CH:3]=[C:4]([CH:9]=[C:10](Cl)[N:11]=1)[C:5](OC)=O.[CH3:13]NS(C)(=O)=O.Cl[C:20]1[CH:21]=[C:22]([CH:26]=[C:27]([N:29]([CH3:34])[S:30]([CH3:33])(=[O:32])=[O:31])[N:28]=1)[C:23]([OH:25])=[O:24]>>[CH3:5][C@H:4]1[CH2:3][CH:9]1[C@H:10]([NH:11][C:20]1[CH:21]=[C:22]([CH:26]=[C:27]([N:29]([CH3:34])[S:30]([CH3:33])(=[O:32])=[O:31])[N:28]=1)[C:23]([OH:25])=[O:24])[CH3:13]

Participants

Reactant 3

HCID 93237Methyl 2,6-dichloroisonicotinate

HCID 97632N-Methylmethanesulfonamide

HCID 167483252-Chloro-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Product 1

HCID 59028312HCID 59028312, compound

Procedure

Prepared from Methyl 2,6-dichloroisonicotinate, methyl(methylsulfonyl)amine and intermediate 3.6.5 following a similar procedure as described for the preparation of intermediate 4.2c.1. MS M+1=328.

Sources & evidence

ORD record: ord-51304356574b425e92fff9a1330ce6c1
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394837B2

Reaction notes

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