HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944588Generated: October 26, 2026
Ethyl 6-chloro-4-hydroxy-3-quinolinecarboxylate → Ethyl 4,6-dichloroquinoline-3-carboxylate
https://huagongshe.com/reaction/1944588
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ethyl 6-chloro-4-hydroxy-3-quinolinecarboxylate | HCID 718113 | — |
| Reactant | HCID 178479711 | HCID 178479711 | — |
| Product | Ethyl 4,6-dichloroquinoline-3-carboxylate | HCID 1479087 | — |
Reaction Steps
Ethyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (19.8 mmol) and phosphorus (V) oxychloride (99.3 mmol) was stirred and heated to 125° C. for 12 hours. The mixture was cooled to ambient temperature and the phosphorus (V) oxychloride was evaporated. The crude product was used without further purification. MS m/z 271.80 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394818B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-e2164671797e42239db7f524f00b5bec |
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| Source note | uspto-grants-2013_03 |
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