Diisopropylethylamine → HCID 131730291, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-6-methoxybenzothiazole (0.17 g, 1.0 mmol), octahydropyrido[1,2-a]-pyrazine (0.21 g, 1.0 mmol), DIPEA (0.51 mL) and dimethylsulfoxide (1 mL) was stirred at 115° C. overnight. The reaction mixture was allowed to cool and dissolved in a mixture of ethyl acetate and a NaHCO3 solution. The phases were separated and the organic phase was washed with water (3×) and then extracted with 0.25 M hydrochloric acid (20 mL). The acidic aqueous extract was concentrated and re-evaporated with ethanol. The residue was crystallized from a mixture of ethanol and ethyl acetate to give 193 mg (57%) of 2-(6-methoxybenzothiazol-2-yl)octahydropyrido[1,2-a]pyrazine, hydrochloride.

Provenance & Evidence