反应详情

温度

160 °C

A mixture of 5-bromo-2-(methylthio)benzothiazole (200 mg, 0.77 mmol), 1-isopropylpiperazine (985 mg, 7.7 mmol) and pyridine (610 mg, 7.7 mmol) was heated at 160° C. for 36 h. The reaction mixture was concentrated under reduced pressure and the residue was extracted with dichloromethane (3×10 mL). The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated. The residue was purified by column chromatography on silica gel (eluent: 2% EtOAc in Petroleum ether) to give 200 mg (77%) of 5-bromo-2-(4-isopropylpiperazin-1-yl)benzothiazole.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionthe residue was extracted with dichloromethane (3×10 mL)
3. washThe combined organic extracts were washed with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe residue was purified by column chromatography on silica gel (eluent: 2% EtOAc in Petroleum ether)