HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2-(4-Cyclopropylpiperazin-1-yl)benzooxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-(4-Cyclopropylpiperazin-1-yl)benzooxazole-5-carbonitrile | HCID 23728897 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 2-(4-Cyclopropylpiperazin-1-yl)benzooxazole | HCID 47453664 | 111.1% |
Reaction Steps
To a solution of 2-(4-cyclopropylpiperazin-1-yl)benzooxazole-5-carbonitrile (500 mg, 1.85 mmol) in MeOH-THF (12 mL, 5:3) was added NH4OH (1.5 mL) and Raney Ni (100 mg). The mixture was stirred for 12 h at rt under a H2 atmosphere. After filtration, the mixture was concentrated to give 5-aminomethyl-[2-(4-cyclopropylpiperazin-1-yl)benzooxazole (500 mg, 99%), which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394842B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-209de00905cf4560a0538d5b6b7a9481 |
| Source note | uspto-grants-2013_03 |