Dichloromethane → HCID 178462115, compound

Participants

Reaction Steps

tert-Butyl trans-4-((R)-1-phenylethylcarbamoyl)cyclohexylcarbamate (Intermediate 41, 5.2 g) was dissolved in DCM (50 mL) to which TFA was added. The resulting mixture was stirred for 45 min at room temperature. LC-MS of material showed one major peak which corresponded to desired product. The reaction mixture was then concentrated to give a clear oil. The oil was then dissolved in diethyl ether (200 mL) to which HCl (2M solution in ether) (20 mL) was added. The resulting mixture was stirred at room temperature for 2 h, resulting in a white precipitate that was collected by filtration and washed with diethyl ether (4.1 g).

Provenance & Evidence