HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 4-aminocyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2,2-Dimethoxypropane | HCID 6495 | — |
| Reactant | 4-(((Tert-butoxy)carbonyl)amino)cyclohexane-1-carboxylic acid | HCID 2755996 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-aminocyclohexanecarboxylate | HCID 422580 | 103.8% |
Reaction Steps
(1r,4r)-4-(tert-Butoxycarbonylamino)cyclohexanecarboxylic acid (25 g, 103 mmol) was dissolved in MeOH (250 ml), to which 2,2-dimethoxypropane (10.70 g, 12.63 ml, 103 mmol) and then 2M HCl in ether (51 ml, 103 mmol) were added. The reaction mixture was stirred at room temperature overnight, then concentrated and the residue was treated with ether (100 ml). The resulting white suspension was filtered then dried to afford a white powder (16.8 g, 84% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394858B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d159148976bd42a5a75f9591b7a56504 |
| Source note | uspto-grants-2013_03 |