Lithium Hydroxide → HCID 58291968, compound

Participants

Reaction Steps

4-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-cyclohexanecarboxylic acid ethyl ester (Intermediate 78, 1.35 g) was hydrolyzed to an acid by adding it to 45 ml of a solution of 1M LiOH in 1:1 THF:MeOH: at room temperature. The pH was adjusted to 3 and the mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered, and concentrated to give the title compound. MS MH+ 275.4

Provenance & Evidence