HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R)-(+)-1-(4-Fluorophenyl)ethylamine → HCID 67224135, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R)-(+)-1-(4-Fluorophenyl)ethylamine | HCID 6950187 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58291968 | HCID 58291968 | — |
| Product | HCID 67224135 | HCID 67224135 | 44% |
Reaction Steps
4-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-cyclohexanecarboxylic acid (Intermediate 79, 1.15 g) and with (R)-1-(4-Fluoro-phenyl)-ethylamine (640 mg) were coupled using the standard HATU coupling procedure as described in Example 1 to yield a 3:2 mixture (A:B) of diastereomers the title compound (44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394858B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-bd621ed8f3464e9ba854b1ef5a5ffdf4 |
| Source note | uspto-grants-2013_03 |