Benzylamine → HCID 3784878, compound

HRID 1944727Notes

Reaction equation

HRID 1944727 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.ClC1C=CC(S(N[C@H]2CC[C@H](C(OC)=O)CC2)(=O)=O)=CC=1[N+]([O-])=O>>[CH2:15]([NH:22][S:9]([C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:14])([F:13])[F:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178501250HCID 178501250, compound

Product 1

HCID 3784878HCID 3784878, compound

Procedure

4-(Trifluoromethyl)benzene-1-sulfonyl chloride (1 gm) was coupled to benzylamine using conditions analogous to those used to prepare intermediate 1. Purification by chromatography yielded N-benzyl-4-(trifluoromethyl)benzenesulfonamide (770 mg). Rf=0.38 by TLC eluting with 30% ethyl acetate in heptane. MS MH+ 316.2

Workup

  1. customPurification by chromatography

Sources & evidence

ORD record
ord-0bccd4e5e4b4404bbba1f6dc50e67989
Source dataset
uspto-grants-2013_03
Patent number
US08394858B2

Reaction notes

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