HCID 58291919, compound → HCID 58292070, compound

Participants

Reaction Steps

(R)-tert-butyl 4-(benzylamino)-1-(1-(4-fluorophenyl)ethylcarbamoyl)cyclohexylcarbamate (Intermediate 94, the “cis” isomer, 87 mg) was hydrogenated at 1 atm hydrogen gas using 10% Pd/C (26 mg, Degussa type E101 NE/W 50% wet) for 16 hours. The reaction was filtered over celite to yield {4-Amino-1-[(R)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester (70 mg). MS MH+ 380.4

Provenance & Evidence