4-(Trifluoromethyl)benzenesulfonamide → HCID 67224524, compound

HRID 1944745Notes

Reaction equation

HRID 1944745 reaction equation
[CH3:1][O:2][C:3]([C:5]12[CH2:12][CH2:11][C:8]([NH2:13])([CH2:9][CH2:10]1)[CH2:7][CH2:6]2)=[O:4].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:21]=[CH:20][C:19]([S:22](N)(=[O:24])=[O:23])=[CH:18][CH:17]=1.ClC1C=CC(S(N[C@H]2CC[C@H](C(OC)=O)CC2)(=O)=O)=CC=1[N+]([O-])=O>>[F:27][C:15]([F:14])([F:26])[C:16]1[CH:17]=[CH:18][C:19]([S:22]([NH:13][C:8]23[CH2:9][CH2:10][C:5]([C:3]([O:2][CH3:1])=[O:4])([CH2:12][CH2:11]2)[CH2:6][CH2:7]3)(=[O:24])=[O:23])=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 700184-(Trifluoromethyl)benzenesulfonamideHCID 53426661Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylateHCID 178501250HCID 178501250, compound

Product 1

HCID 67224524HCID 67224524, compound

Procedure

Methyl 4-(4-(trifluoromethyl)phenylsulfonamido)bicyclo[2.2.2]octane-1-carboxylate was prepared from 4-aminobicyclo[2.2.2]octane-1-carboxylic acid methyl ester and 4-trifluoromethylbenzene sulfonamide using a method analogous to the method used to prepare Intermediate 1.

Sources & evidence

ORD record
ord-991567f99e2e42d1bdddb7077dc6f0d6
Source dataset
uspto-grants-2013_03
Patent number
US08394858B2

Reaction notes

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