Isopropyl iodide → HCID 178493634, compound

Participants

Reaction Steps

Trans-N—((R)-1-(4-Fluorophenyl)ethyl)-4-(4-hydroxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide (Example 2, 14 mg, 0.031 mmol), 2-iodopropane (4 ul, 0.037 mmol), K2CO3 (21 mg, 0.155 mmol) and tetrabutylammonium iodide (TBAI, 3 mg, cat) were dissolved in DMF (0.5 ml) and the reaction was stirred at room temperature for 15 hr under nitrogen. LCMS indicated that the reaction was complete, and the crude material was purified via reverse phase chromatography on prep-HPLC (150 mm, C8 luna, 15-20 min run, 10%-100% MeCN in water containing 0.1% TFA). Fractions containing the product were lyophilized to yield the title compound as a white solid (6.4 mg, 42%). MS MH+ 493.1

Provenance & Evidence