Methanol → HCID 178494217, compound

Participants

Reaction Steps

Trans-4-(5-Bromo-6-chloro-pyridine-3-sulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide (Example 144, 484 mg, 0.933 mmol) was dissolved in a solution of NaOMe in MeOH (0.5M, 28 ml, 13.99 mmol). The reaction mixture was stirred overnight at room temperature. LCMS indicated that the reaction was complete and it was concentrated in vacuo then taken up in EtOAc and purified via column chromatography using a biotage SP1, 40+M column, with 50% EtOAc in heptane as calculated gradient to yield the title compound as a white solid (313 mg, 65%). [M+H]=516.0

Provenance & Evidence