Dimethylamine → HCID 178462128, compound

Participants

Reaction Steps

Trans-4-(5-Bromo-6-chloro-pyridine-3-sulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide (Example 241, 300 mg, 0.580 mmol) was dissolved in NMP (3 ml). DIPEA (202 ul, 1.16 mmol) was added followed by dimethylamine in THF (2M, 0.87 ml, 1.74 mmol). The reaction mixture was microwaved at 160° C. for 15 min., after which LCMS indicated that the reaction was complete. The mixture was diluted with EtOAc and washed H2O. The organic layer was concentrated in vacuo and purified via column chromatography using a biotage SP1, 12+M column, with 50% EtOAc in heptane as calculated gradient to yield the title compound as a white solid (258 mg, 84%). MS MH+ 529.9

Provenance & Evidence