Tetra-n-butylammonium tribromide → HCID 178462124, compound

Participants

Reaction Steps

Tetrabutylammonium-tribromide (216 mg, 0.447 mmol) was added to solution of trans-4-(4-acetyl-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide (Example 104, 194 mg, 0.434 mmol) in DCM/MeOH (2/1, 1.45 ml) at room temperature. The reaction was stirred 16-40 hours, then concentrated and partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was dried over magnesium sulfate and concentrated to crude product which was chromatographed on a Biotage 40S column using ethyl acetate/heptane as the eluent to give the title compound (122 mg, 0.232 mmol).

Provenance & Evidence