Magnesium 2-(dioxidan-2-ide-1-carbonyl)benzoate--water (1/1/6) → HCID 178462122, compound

Participants

Reaction Conditions

Reaction Steps

Magnesium monoperoxyphthalate hexahydrate (66.8 mg, 0.135 mmol) was suspended in MeOH (0.5 ml) and cooled to 0° C. Trans-4-(4-pyridin-4-yl-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide (Example 284, 50 mg, 0.097 mmol) in DCM (0.5 ml) was added dropwise and the reaction mixture was left to stir overnight at 23° C. LCMS indicated that the reaction was complete, and the mixture was concentrated in vacuo to a residue which was purified by reverse phase chromatography on prep-HPLC (150 mm, C8 luna, 15-20 min run, 10%-100% MeCN in water containing 0.1% TFA). Product containing fractions were lyophilized to yield the title compound (10 mg, 21%). MS MH+ 498.1

Provenance & Evidence