HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (R)-1-[3-Amino-4-(benzyloxy)phenyl]-2-bromoethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (R)-1-(4-Benzyloxy-3-nitrophenyl)-2-bromoethanol | HCID 10882679 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (R)-1-[3-Amino-4-(benzyloxy)phenyl]-2-bromoethanol | HCID 11232489 | — |
Reaction Steps
(R)-1-[4-(Benzyloxy)-3-nitrophenyl]-2-bromoethanol (0.200 g, 0.569 mmol) in 1:1 THF:toluene (5 mL) was reacted with PtO2 (1% w/w) on a Parr shaker at 45 psi at rt overnight. The next morning the PtO2 was removed by filtration over celite. The product was concentrated to give the title compound. ES/MS calcd. for C15H17BrNO2+ 322.0. Found m/z=322 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-73a29b1947df4e6cbecb54eecbd6987e |
| Source note | uspto-grants-2013_03 |