3-Aminophenylboronic acid → Methyl 4-(3'-amino-[1,1'-biphenyl]-4-yl)butanoate

HRID 1944863Notes

Reaction equation

HRID 1944863 reaction equation
N[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH2:21]C1C=C(B(O)O)C=CC=1>>[NH2:21][C:3]1[CH:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:10][CH:9]=2)[CH:6]=[CH:7][CH:2]=1

Participants

3

Reactant 2

HCID 922693-Aminophenylboronic acidHCID 57516934Methyl 4-(4'-amino-[1,1'-biphenyl]-4-yl)butanoate

Product 1

HCID 57516935Methyl 4-(3'-amino-[1,1'-biphenyl]-4-yl)butanoate

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 29, using (3-aminophenyl)boronic acid as in place of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline ES/MS calcd. for C17H20NO2+ 270.2. Found m/z=270.2 (M+H)+.

Sources & evidence

ORD record
ord-78aa61431d2f4120a2b5263ffd9b55ac
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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