6-((4-Bromophenyl)thio)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → 6-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

HRID 1944889Notes

Reaction equation

HRID 1944889 reaction equation
OCCCCC[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][S:13]([C:16]1[CH:17]=[C:18]2[C:23](=[C:24]([CH3:26])[CH:25]=1)[N:22]=[CH:21][C:20]([C:27]([NH2:29])=[O:28])=[C:19]2[NH:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH3:38])[CH:32]=1)(=[O:15])=[O:14].[Br:39]C1C=CC(SC2C=C3C(=C(C)C=2)N=CC(C(N)=O)=C3NC2C=CC=C(OC)C=2)=CC=1>>[Br:39][C:9]1[CH:8]=[CH:7][C:12]([S:13]([C:16]2[CH:17]=[C:18]3[C:23](=[C:24]([CH3:26])[CH:25]=2)[N:22]=[CH:21][C:20]([C:27]([NH2:29])=[O:28])=[C:19]3[NH:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH3:38])[CH:32]=2)(=[O:15])=[O:14])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 585050946-((4-Bromophenyl)thio)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 66988573HCID 66988573, compound

Product 1

HCID 669882586-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 61, using Intermediate 60 as a substrate. ES/MS calcd. for C24H21BrN3O4S+ 526.0. Found m/z=526.1 (M+H)+.

Sources & evidence

ORD record
ord-61f81061f0a04092a68d109d125784d7
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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